Drug-induced hypersensitivity syndrome
(DIHS에서 넘어옴)
과민 증후군(hypersensitivity syndrome, Drug-induced hypersensitivity syndrome, DIHS)
임상 양상
- 피부병변+ 혈액, 폐, 간, 콩팥, 심장 등 침범
- 원인 약물: Allopurinol(m/c)[1], Phenytoin, Carbamazepine, Phenobarbital, Sulfasalazine, sulfonamide, Dapsone 등
치료
- Systemic glucocorticoids(prednisone 1 - 2 mg/kg daily) with slow taper over 8- 12 weeks.
- mycophenolate mofetil: rapid recurrence upon steroid taper.
- ↑ Harrison 19th Ed. p382