"Hypersensitivity reaction"의 두 판 사이의 차이
(새 문서: 분류:Disease 분류:Allergy 과민반응(Hypersensitivity reaction) ==분류== *Type I Immediate type hypersensitivity( IgE depedent or anaphylactic) **ex) Allergic rhnitis...) |
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| (같은 사용자의 중간 판 9개는 보이지 않습니다) | |||
| 1번째 줄: | 1번째 줄: | ||
| − | [[분류:Disease]] [[분류:Allergy]] | + | [[분류:Disease]] [[분류:Allergy]] [[분류:Immunology]] |
| − | + | [[과민 반응]](Hypersensitivity reaction, Hypersensitivity types)은 면역 체계에 의한 원치 않는 반응으로 기전에 따라 크게 4가지로 분류한다. . | |
==분류== | ==분류== | ||
| + | ===[[Type 1 hypersensitivity]]=== | ||
*Type I Immediate type hypersensitivity( IgE depedent or anaphylactic) | *Type I Immediate type hypersensitivity( IgE depedent or anaphylactic) | ||
| − | **ex) Allergic rhnitis, asthma, systemic anaphylaxis | + | **ex) [[Allergic rhnitis]], [[asthma]], systemic [[anaphylaxis]], Drug allergies([[penicillin]], [[insulin]], [[cephalosporin]]) |
| + | |||
| + | ===[[Type 2 hypersensitivity]]=== | ||
*Type IIa Cytotoxic or cytolytic reactions | *Type IIa Cytotoxic or cytolytic reactions | ||
**ex) Drug allergies(penicillin) | **ex) Drug allergies(penicillin) | ||
*Type IIb Cell stimulating reactions involving altered cell function | *Type IIb Cell stimulating reactions involving altered cell function | ||
| − | **ex) Chronic urticaria | + | **ex) Chronic [[urticaria]] |
| + | |||
| + | ===[[Type 3 hypersensitivity]]=== | ||
*Type III Antigen-antibody complex(immune complex) hypersensitivity reaction | *Type III Antigen-antibody complex(immune complex) hypersensitivity reaction | ||
| − | **ex) Serum sickness, Arthus reaction | + | **ex) [[Serum sickness]], [[PSGN]], [[SLE]], [[Arthus reaction]] |
| + | |||
| + | ===[[Type 4 hypersensitivity]]=== | ||
| + | Delayed type hypersensitivity로 sensitized T lymphocyte가 Ag을 만나 cytokine 분비 및 macrophage 활성화 | ||
*Type IVa1 Classical delayed type | *Type IVa1 Classical delayed type | ||
| − | **ex) Contact dermatitis, tuberculin reaction | + | **ex) [[Contact dermatitis]], [[tuberculin reaction]]([[tuberculin skin test]]) |
*Type IVa2 Cell mediated eosinophlic(or Chronic allergic inflammation | *Type IVa2 Cell mediated eosinophlic(or Chronic allergic inflammation | ||
| − | **ex) Chronic asthma, chronic allergic rhinitis | + | **ex) Chronic [[asthma]], chronic [[allergic rhinitis]] |
*Type IVb Tissue injury by cytotoxic T cell | *Type IVb Tissue injury by cytotoxic T cell | ||
| − | **ex) contact dermatitis | + | **ex) [[contact dermatitis]] |
==IgE Ab crosslink에 의한 mast cell 활성화 기전== | ==IgE Ab crosslink에 의한 mast cell 활성화 기전== | ||
| 26번째 줄: | 34번째 줄: | ||
==호산구의 Toxic protein== | ==호산구의 Toxic protein== | ||
| − | *MBP(Major basic protein) | + | *[[MBP]]([[Major basic protein]]) |
| − | *ECP(Eosinophil cationic protein) | + | *[[ECP]]([[Eosinophil cationic protein]]) |
*EDN(Eosinophil-derived neurotoxin) | *EDN(Eosinophil-derived neurotoxin) | ||
2016년 7월 2일 (토) 01:39 기준 최신판
과민 반응(Hypersensitivity reaction, Hypersensitivity types)은 면역 체계에 의한 원치 않는 반응으로 기전에 따라 크게 4가지로 분류한다. .
목차
분류
Type 1 hypersensitivity
- Type I Immediate type hypersensitivity( IgE depedent or anaphylactic)
- ex) Allergic rhnitis, asthma, systemic anaphylaxis, Drug allergies(penicillin, insulin, cephalosporin)
Type 2 hypersensitivity
- Type IIa Cytotoxic or cytolytic reactions
- ex) Drug allergies(penicillin)
- Type IIb Cell stimulating reactions involving altered cell function
- ex) Chronic urticaria
Type 3 hypersensitivity
- Type III Antigen-antibody complex(immune complex) hypersensitivity reaction
- ex) Serum sickness, PSGN, SLE, Arthus reaction
Type 4 hypersensitivity
Delayed type hypersensitivity로 sensitized T lymphocyte가 Ag을 만나 cytokine 분비 및 macrophage 활성화
- Type IVa1 Classical delayed type
- Type IVa2 Cell mediated eosinophlic(or Chronic allergic inflammation
- ex) Chronic asthma, chronic allergic rhinitis
- Type IVb Tissue injury by cytotoxic T cell
IgE Ab crosslink에 의한 mast cell 활성화 기전
- Allergen cross linkage of cell-bound IgE
- Antibody cross-linkage of IgE
- chemical cross linkage of IgE
- cross-linkage of IgE receptors by anti-receptor antibody
- enchanced Ca2+ influx by ionophore that increases membrane permeability to Ca2+
호산구의 Toxic protein
- MBP(Major basic protein)
- ECP(Eosinophil cationic protein)
- EDN(Eosinophil-derived neurotoxin)