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Pemphigus vulgaris

심상성 천포창(pemphigus vulgaris)는 자가 면역으로 인한 수포성 피부 질환이다.

임상 양상

  • Potentially fatal autoimmune skin disorder with IgG against desmoglein(component of desmosomes).
  • Flaccid intraepidermal bullae caused by acantholysis(keratinocytes in stratum spinosum are connected by desmosomes); oral mucosa also involved.
  • Immunofluorescence: Abs around epidermal cells in a reticular (net-like) pattern.
  • Nikolsky sign(+)

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