Pemphigus vulgaris
심상성 천포창(pemphigus vulgaris)는 자가 면역으로 인한 수포성 피부 질환이다.
임상 양상
- Potentially fatal autoimmune skin disorder with IgG against desmoglein(component of desmosomes).
- Flaccid intraepidermal bullae caused by acantholysis(keratinocytes in stratum spinosum are connected by desmosomes); oral mucosa also involved.
- Immunofluorescence: Abs around epidermal cells in a reticular (net-like) pattern.
- Nikolsky sign(+)