Tumor suppressor gene

종류

APC: Colorectal cancer (associated with FAP)
BRCA1/BRCA2: Breast and ovarian cancer, DNA repair protein
CDKN2A: Melanoma, pancreatic cancer p16, blocks G1, S phase
DCC: Colon cancer, DCC—Deleted in Colon Cancer
DPC4/SMAD4: Pancreatic cancer DPC—Deleted in Pancreatic Cancer
MEN1: MEN 1 Menin
NF1: NeuroFibromatosis type 1 Ras GTPase activating protein (neurofibromin)
NF2: NeuroFibromatosis type 2 Merlin (schwannomin) protein
PTEN: Breast cancer, prostate cancer, endometrialcancer
Rb: Retinoblastoma, osteosarcoma Inhibits E2F; blocks G1 S phase
TP53(p53): Most human cancers, Li-Fraumeni syndrome p53, activates p21, blocks G1 S phase
TSC1: Tuberous sclerosis Hamartin protein
TSC2: Tuberous sclerosis Tuberin protein
VHL: von Hippel-Lindau disease, renal cellcarcinoma Inhibits hypoxia inducible factor 1a
WT1/WT2: Wilms Tumor (nephroblastoma)