Glucocorticoid

글루코코티코이드(Glucocorticoid, GC)는 항염증 효과 및 면역억제 효과가 있는 corticosteroid 약물이다.

종류

• Beclomethasone
• dexamethasone
• hydrocortisone
• methylprednisolone
• prednisone
• triamcinolone

기전

• Metabolic, catabolic, anti-inflammatory, and immunosuppressive effects mediated by interactions

with glucocorticoid response elements, inhibition of phospholipase A 2 , and inhibition of transcription factors such as NF-κB.

부작용

• Iatrogenic Cushing syndrome
• adrenocortical atrophy
• peptic ulcers
• steroid diabetes
• steroid psychosis
• cataracts
• Adrenal insufficiency: 테이퍼링 없이 중단시